Key result
HELP reduces lipoproteins and fibrinogen by ~50% and improves coronary vasodilation capacity.
Heparin-induced extracorporeal LDL precipitation (HELP) provides significant acute reductions in LDL and fibrinogen, which translates to improved endothelial function and coronary vasodilation.
Heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) is a selective and careful apheresis procedure. Through the application of heparin and lowering the pH value, lipoproteins and fibrinogen are reduced by 50-60%. In addition, adhesion molecules (ICAM-1, VCAM-1, p-selectin) which play a key role in the development and progression of atherosclerosis, are also markedly reduced. A PET scan performed 20 h after LDL apheresis shows the improvement of coronary vasodilation capacity. This is supposed to be mainly due to the marked reduction of LDL cholesterol and fibrinogen with consecutive improvement of endothelial dysfunction and rheology.
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Klaus‐Peter Mellwig (2003) conducted a review in Atherosclerosis. Heparin-induced extracorporeal low-density lipoprotein precipitation (HELP) was evaluated on Reduction of lipoproteins and fibrinogen. Heparin-induced extracorporeal LDL precipitation (HELP) reduces lipoproteins and fibrinogen by 50-60% and improves coronary vasodilation capacity.
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