Key result
Increasing age is linked to lower urinary 11-dehydrothromboxane B2 levels in healthy pediatric subjects.
Why the study?
Reference ranges of urinary 11-dehydrothromboxane B2 in healthy pediatric subjects were not established to understand age-related differences in developmental hemostasis.
Cross-Sectional (n=128)
p-value: p=0.0001
This study establishes age-specific reference ranges for urinary 11-dehydrothromboxane B2 in healthy pediatric subjects, demonstrating a negative correlation with age.
Provides age-adjusted pediatric reference ranges for urinary 11-dhTXB2; leaves open their role in guiding antiplatelet therapy.
Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P = 0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.
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Varnell et al. (2014) conducted a cross-sectional in Healthy (n=128). Age was evaluated on Correlation between age and level of urinary 11-dehydrothromboxane B2 (p=0.0001). Age was negatively correlated with urinary 11-dehydrothromboxane B2 levels in healthy pediatric subjects (P = 0.0001).
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