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January 1, 2002Stroke

Median urinary 11-DTB2 was 783 pg/mg creatinine in patients taking daily aspirin compared with 1386 pg/mg creatinine in patients not taking daily aspirin (P=0.01).

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Why the study?

Does daily aspirin use reduce urinary 11-dehydrothromboxane B2 in African American stroke patients?

Population

87 African American patients within 4 months of noncardioembolic ischemic stroke, not treated with…

Comparison

Daily aspirin use vs No aspirin

Design

Cross-sectional

Follow-up

1 to 4 months after stroke

Authors

ABAskiel BrunoJMJoseph P. McConnellHMHarry H. Mansbach

Discussion

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Overview

Daily aspirin was associated with lower 11-DTB2 in African American stroke patients; hypothesis-generating and requires prospective outcome trials.

Structured PICO

Does daily aspirin use reduce urinary 11-dehydrothromboxane B2 in African American stroke patients?

P
Population
87 African American patients within 4 months of noncardioembolic ischemic stroke, not treated with anticoagulants. Mean age 62, 51 men.
I
Intervention
Daily aspirin use (doses ranging from 81 to 1300 mg/day)
C
Comparator
No aspirin (no antithrombotic drugs [n=4] or ticlopidine [n=12])
O
Outcome
Urinary excretion of 11-dehydrothromboxane B2 (11-DTB2) measured 1 to 4 months after strokesurrogate

In African American stroke patients, daily aspirin use is associated with significantly lower urinary 11-DTB2 levels compared to no aspirin, with no apparent dose-response effect between 325 and 1300 mg daily.

Cite This Study

Bruno et al. (2002) studied this question.

synapsesocial.com/papers/6a72724dfebe604dd70a9bdchttps://doi.org/10.1161/hs0102.102010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serial Urinary 11-Dehydrothromboxane B2, Aspirin Dose, and Vascular Events in Blacks After Recent Cerebral Infarction2004 · 29 citations
  2. 2Aspirin Dosage and Thromboxane Synthesis in Patients with Vascular Disease2003 · 71 citations
  3. 311-dehydrothromboxane B2 as a marker of acetylsalicylic acid resistance in patients with stable coronary artery disease2023
  4. 4High Risk of Cardiovascular Events in Patients, Biosynthesis of Aspirin-Resistant Thromboxane And The Risk Of Stroke, Myocardial Infarction Or Death2022
  5. 5Aspirin resistance in Indian patients with coronary artery disease and cardiovascular events2009 · 12 citations