What is the clinical evidence from this study?

Study design: Editorial. Intervention: Exercise training vs. Sedentary control.

What does this research mean for the field?

Exercise training enhances neuronal nitric oxide-mediated functional sympatholysis during muscle contraction through increased nNOS expression, although redundant non-nitric oxide mechanisms also preserve sympatholytic capacity. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 26, 2015The Journal of PhysiologyOpen Access

Is nitric oxide mediated sympatholysis improved with exercise? Yes or nNO?

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Key result

Exercise training enhanced neuronal nitric oxide (nNO) mediated inhibition of sympathetic vasoconstriction during muscle contraction in rats, though NOS blockade did not completely abolish sympatholysis.

Why the study?

Does exercise training improve nNO-mediated inhibition of sympathetic vasoconstriction during muscle contraction in rats?

Population

Sedentary and exercise-trained rats

Comparison

4 weeks of exercise training vs Sedentary time control interventions

Design

Editorial

Follow-up

4 weeks

Authors

RHRyan L. HoilandUniversity of British Columbia

Discussion

Member takes

Implication

This editorial highlights that exercise training improves functional sympatholysis in rats by enhancing neuronal nitric oxide-mediated inhibition of sympathetic vasoconstriction.

Structured PICO

Does exercise training improve nNO-mediated inhibition of sympathetic vasoconstriction during muscle contraction in rats?

Population

Sedentary and exercise-trained rats

Exposure

4 weeks of exercise training

Comparator

Sedentary time control interventions

Outcome

Femoral vascular conductance (FVC) during lumbar sympathetic stimulation at rest and during rhythmic contraction of the triceps surae musclessurrogate

This editorial highlights that exercise training improves functional sympatholysis in rats by enhancing neuronal nitric oxide-mediated inhibition of sympathetic vasoconstriction.

Limitations

Evoked contraction via sciatic stimulation in dissected muscle does not completely represent normal physiological afference and efference.
Superimposing sympathetic stimuli may affect the interpretation of sympatholytic responses compared to naturally occurring stimuli.
Evoked contraction via sciatic stimulation does not completely represent normal physiological afference and efference
Superimposing sympathetic stimuli may affect the interpretation of sympatholytic responses

Cite This Study

Ryan L. Hoiland (2015) reported an editorial. Exercise training vs. Sedentary control was evaluated. Exercise training enhanced neuronal nitric oxide (nNO) mediated inhibition of sympathetic vasoconstriction during muscle contraction in rats, though NOS blockade did not completely abolish sympatholysis.

synapsesocial.com/papers/6aaddfdead4280f693b8acd8 https://doi.org/10.1113/jphysiol.2014.286815

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Implication

This editorial highlights that exercise training improves functional sympatholysis in rats by enhancing neuronal nitric oxide-mediated inhibition of sympathetic vasoconstriction.

Is nitric oxide mediated sympatholysis improved with exercise? Yes or nNO?

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Is nitric oxide mediated sympatholysis improved with exercise? Yes or nNO?

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider