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April 1, 2004Journal of Biological ChemistryOpen Access

DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage

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Authors

MJMelissa T. JackRWRichard A. WooSouthern Illinois University School of MedicineNMNoboru MotoyamaSugiyama Jogakuen University

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Jack et al. (2004) studied this question.

synapsesocial.com/papers/6aaddff0fc6d9605b2db8bd5https://doi.org/10.1074/jbc.m309917200
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chk2 is dispensable for p53-mediated G 1 arrest but is required for a latent p53-mediated apoptotic response2002 · 141 citations
  2. 2Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response2003 · 98 citations
  3. 3The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells2003 · 153 citations