Key result
Transcriptome analysis identifies RPS4Y1 and MYH6 as common differential genes in DCMi and ICM.
Why the study?
The associated genes and biological pathways of inflammatory dilated cardiomyopathy and ischemic cardiomyopathy were not fully characterized using transcriptome data.
Bioinformatics analysis reveals distinct biological pathways in inflammatory dilated cardiomyopathy (PPAR signaling) and ischemic cardiomyopathy (ECM-receptor interaction), suggesting potential therapeutic targets.
Does not guide clinical differentiation of DCMi versus ICM; leaves open targeted validation of RPS4Y1, MYH6, and pathways in prospective studies.
Objectives: To screen the associated genes and biological pathways of inflammatory dilated cardiomyopathy (DCMi) and ischemic cardiomyopathy (ICM) a transcriptome data method. Materials and Methods:The differential genes (DEGs) were analyzed by the transcriptome data of DCMi and ICM in the comprehensive gene expression database, then the cluster analysis and Hub gene candidate genes were identified by Cytoscape, and the biological pathway of candidate genes was studied by GO and KEGG enrichment analysis. Results:The common DEGs of DCMi and ICM were RPS4Y1 and MYH6.The biological processes in the GO analysis of DCMi are mainly related to the development and regulation of muscle and cardiomyocytes, while ICM is mainly related to biological processes such as extracellular matrix and collagen.Through KEGG analysis, we found that the DEGs in DCMi were mainly enriched in the PPAR signaling pathway (inhibition).In ICM, mainly enriched in ECM-receptor interaction (activation). Conclusion:Our results reveal the related genes and biological pathways of DCMi and ICM, and we believe that the activation of the PPAR signaling pathway is expected to alleviate and improve myocardial inflammation.In ICM, it is possible to regulate the signal pathway of ECM-receptor interaction by increasing the transcriptional levels of COL3A1, COL1A1, and COL1A2, thus further promoting the progression of the disease.
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Weichen Si (2023) studied Inflammatory dilated cardiomyopathy (DCMi) and ischemic cardiomyopathy (ICM). Transcriptome data analysis was evaluated on Differential genes (DEGs) and biological pathways. Transcriptome analysis identified RPS4Y1 and MYH6 as common differential genes, with DCMi enriched in PPAR signaling inhibition and ICM enriched in ECM-receptor interaction activation.
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