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July 14, 2021Blood Cancer DiscoveryOpen Access

ZBTB33 Is Mutated in Clonal Hematopoiesis and Myelodysplastic Syndromes and Impacts RNA Splicing

Ellen M. Beauchamp Matthew Leventhal Elsa Bernard Emma R. Hoppe Gabriele Todisco Maria Creignou Anna Gallì Cecilia A. Castellano Marie McConkey Akansha Tarun Waihay J. Wong Monica Schenone Caroline R. Stanclift Benjamin Tanenbaum Edyta Małolepsza Alexander G. Bick Joshua S. Weinstock Mendy Miller Abhishek Niroula Andrew Dunford Amaro Taylor‐Weiner Timothy Wood Alex Barbera Shankara Anand Bruce M. Psaty Pinkal Desai Michael H. Cho Andrew D. Johnson Ruth J. F. Loos Daniel G. MacArthur Monkol Lek Donna Neuberg Kasper Lage Steven A. Carr Eva Hellström‐Lindberg Luca Malcovati Elli Papaemmanuil Chip Stewart Gad Getz Robert K. Bradley Siddhartha Jaiswal Benjamin L. Ebert

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Abstract

mutations potentially link DNA methylation and RNA splicing, the two most commonly mutated pathways in clonal hematopoiesis and MDS.

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Cite This Study

Beauchamp et al. (2021) studied this question.

synapsesocial.com/papers/6aade125919016ad6d0dca62 https://doi.org/10.1158/2643-3230.bcd-20-0224

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Age-Related Clonal Hematopoiesis Associated with Adverse OutcomesOriginal Research · 2014 · 4,825 citations
2Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA SequenceOriginal Research · 2014 · 3,525 citations
3Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromesOriginal Research · 2015 · 1,970 citations
4Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderlyOriginal Research · 2017 · 777 citations
5Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesisOriginal Research · 2014 · 152 citations

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