⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

January 1, 2016Organic & Biomolecular Chemistry

Reversibility of the thia-Michael reaction of cytotoxic C 5 -curcuminoid and structure–activity relationship of bis-thiol-adducts thereof

Aki Kohyama Michihiro Fukuda Shunsuke Sugiyama Hiroyuki Yamakoshi Naoki Kanoh Chikashi Ishioka Hiroyuki Shibata Yoshiharu Iwabuchi

View at Publisher

Ask AI

Bookmark

Share

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Abstract

A panel of GO-Y030-bis-thiol-adducts were synthesized and the structure–reactivity relationship regarding the retro thia-Michael reaction as well as the cell growth inhibitory activity against human colon cancer HCT116 were evaluated.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kohyama et al. (2016) studied this question.

synapsesocial.com/papers/6aade15efc6d9605b2db8c6d https://doi.org/10.1039/c6ob01771a

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 10 related papers. Consider them for comparative context:

1Applying Mechanisms of Chemical Toxicity to Predict Drug SafetyRisk Assessment · 2007 · 231 citations
2Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical PerspectiveOriginal Research · 1998 · 265 citations
3Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational AnalysisOriginal Research · 2014 · 270 citations
4Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancerIn Vitro Study · 2006 · 242 citations
5Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis <i>in vivo</i>Original Research · 2009 · 63 citations
6Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030Original Research · 2015 · 29 citations
7Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivoIn Vitro Study · 2011 · 54 citations
8Amino-derivatives of the sesquiterpene lactone class of natural products as prodrugsOriginal Research · 2012 · 93 citations
9Single-Step Synthesis of 3,5-diazido 1,2,4-triazole: Environmentally Benign High-Performance Primary ExplosivesOrganic & Biomolecular Chemistry · 2026
10Covalently linked diphenylethyne bridged meso -aryl 22-oxabenzonorrole–porphyrin/metalloporphyrin dyadsOrganic & Biomolecular Chemistry · 2026

More from Organic & Biomolecular Chemistry

More from Tohoku University

More from Kumamoto University

More from Graduate School USA

More from Akita University

More from Sendai University