What question did this study set out to answer?

To evaluate whether plasma C-reactive protein (CRP) levels can reliably indicate the severity of COVID-19 pneumonia.

May 15, 2020Annals of Clinical Microbiology and AntimicrobialsOpen Access

Plasma CRP level is positively associated with the severity of COVID-19

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To evaluate whether plasma C-reactive protein (CRP) levels can reliably indicate the severity of COVID-19 pneumonia.
Enrolled symptomatic patients presenting with cough or chest pain (with or without fever) following laboratory confirmation of SARS-CoV-2 by qRT-PCR.
Classified patients into mild, moderate, and severe pneumonia groups using chest computed tomography (CT) scans according to interim management guidelines.
Evaluated the association between plasma CRP levels and disease severity using linear regression and receiver operating characteristic analysis.
Compared to mild pneumonia, elevated plasma CRP yielded an adjusted odds ratio of 11.46 (p = 0.029) for moderate pneumonia and 23.40 (p = 0.025) for severe pneumonia.
Receiver operating characteristic analysis demonstrated strong diagnostic accuracy for disease severity, with an area under the curve of 0.898 (95% CI 0.835 to 0.962, p < 0.001).
Higher plasma CRP concentrations correlated with greater disease severity and longer inpatient hospital stays.

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Implication

Observational study demonstrates elevated plasma C-reactive protein levels track with severe COVID-19 pneumonia, indicating potential utility for early risk stratification and intensive care...

Cite This Study

Chen et al. (2020) studied this question.

synapsesocial.com/papers/6aade1a00e0d4884f9873fdb https://doi.org/10.1186/s12941-020-00362-2

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Implication

Observational study demonstrates elevated plasma C-reactive protein levels track with severe COVID-19 pneumonia, indicating potential utility for early risk stratification and intensive care...

Plasma CRP level is positively associated with the severity of COVID-19

Key Points

Discussion

Implication

Cite This Study

Plasma CRP level is positively associated with the severity of COVID-19

Key Points

Discussion

Implication

Cite This Study

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