What is the clinical evidence from this study?

Study design: Cohort. Population: Degenerative mitral regurgitation (DMR) (n=3666). Intervention: MIDA Score. Primary outcome: Total mortality post-diagnosis (c-statistic 0.81, p=≤0.002).

What does this research mean for the field?

The MIDA Score accurately predicts short- and long-term total mortality in patients with degenerative mitral regurgitation under medical and surgical management, providing incremental prognostic value beyond existing guideline markers and EuroScore II. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 24, 2017European Heart JournalOpen Access

The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation

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Key result

MIDA Score accurately predicts post-diagnosis mortality in degenerative MR with excellent concordance.

c-statistic 0.81
P≤0.002
n=3,666

Why the study?

In degenerative mitral regurgitation, lack of mortality scores predicting death leads to misperception of individual risk and inappropriate decision-making.

Does the MIDA Score accurately predict total mortality in patients with degenerative mitral regurgitation?

Population

3666 patients with pure, isolated degenerative mitral regurgitation diagnosed by echocardiography at tertiary centres

Comparison

Risk stratification by MIDA Score versus standard prognostic markers and EuroScoreII

Design

Cohort study with derivation and external validation cohorts

Follow-up

7.8 ± 5.0 years

Authors

FGFrancesco GrigioniHeart Failure & Transplant MCMarie‐Annick ClavelStructural Heart Disease JVJean‐Louis VanoverscheldeCardiac Imaging

Discussion

Member takes

Implication

MIDA score may aid mortality risk stratification in DMR; leaves open its effect on decisions pending prospective validation.

Study Design

Type

Cohort (n=3,666)

Multicenter

Yes

Structured PICO

Does the MIDA Score accurately predict total mortality in patients with degenerative mitral regurgitation?

Population

3,666 patients (mean age 66 years, 30% female) with pure, isolated degenerative mitral regurgitation, followed for a mean of 7.8 years.

Exposure

MIDA Score risk stratification

Outcome

Total mortality post-diagnosishard clinical

Main Result

Effect estimate: c-statistic 0.81

p-value: p=≤0.002

The MIDA Score is a validated prognostic tool that accurately predicts short- and long-term mortality risk in patients with degenerative mitral regurgitation under medical or surgical management.

Cite This Study

Grigioni et al. (2017) conducted a cohort in Degenerative mitral regurgitation (DMR) (n=3,666). MIDA Score was evaluated on Total mortality post-diagnosis (c-statistic 0.81, p=≤0.002). The MIDA Score accurately predicted total mortality post-diagnosis in patients with degenerative mitral regurgitation, demonstrating excellent concordance in the validation cohort (c = 0.81).

synapsesocial.com/papers/6aade1fda081e442804f6667 https://doi.org/10.1093/eurheartj/ehx465

Topics

Mitral valve intervention Atrial fibrillation Persistent AF management Echocardiography

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The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Topics

The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

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Topics

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