Key result
Baclofen overdose linked to catatonia that improves with lorazepam.
Why the study?
Serious adverse effects of baclofen are uncommon at usual doses, but catatonia secondary to baclofen overdose is rarely reported and not well characterized.
Does baclofen overdose cause catatonia in a previously healthy individual?
Comparison
Baclofen overdose exposure
Design
Case report
Authors
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Baclofen overdose may induce catatonia; single case leaves open causality and should not change practice.
Case Report (n=1)
Does baclofen overdose cause catatonia in a previously healthy individual?
This case report highlights that baclofen overdose can induce catatonia even in previously healthy individuals.
Rissardo et al. (2022) conducted a case report in Baclofen-induced catatonia (n=1). Baclofen was evaluated on Development of catatonia. An intentional overdose of 200 mg of baclofen induced catatonia (Bush-Francis Catatonia Rating Scale score of 27) in a 20-year-old female, which improved with lorazepam.
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