Key result
High-frequency airway oscillations increase genioglossus activity, reversing sleep apnea obstruction in ~46% of NREM trials.
Why the study?
The effects of high-frequency low-pressure oscillations applied to the upper airway on respiratory muscle activity in sleeping humans were not well characterized.
Does high-frequency low-pressure oscillation applied to the upper airway increase respiratory muscle EMG activity in patients with sleep apnea and normal subjects?
Comparison
High-frequency low-pressure oscillations applied to upper airway vs no oscillations
Design
Physiological study measuring EMG responses during sleep
Authors
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Oscillations may augment muscle activity and relieve obstruction in sleep; leaves open therapeutic utility, needs controlled trials.
Does high-frequency low-pressure oscillation applied to the upper airway increase respiratory muscle EMG activity in patients with sleep apnea and normal subjects?
High-frequency low-pressure oscillations applied to the upper airway increase respiratory muscle activity and can partially or completely reverse upper airway obstruction in sleep apnea patients.
Henke et al. (1993) studied Sleep apnea (n=16). High-frequency low-pressure oscillations applied to the upper airway via a nose mask was evaluated on Genioglossus (EMGgg), sternomastoid (EMGsm), and diaphragm electromyogram (EMGdia) activity. High-frequency low-pressure oscillations applied to the upper airway increased peak genioglossus activity in 74% of NREM trials in sleep apnea patients, reversing obstruction in 46% of trials.
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