Laboratory diagnosis of COVID-19

Ekaterini Goudouris

doi:10.1016/j.jped.2020.08.001

August 30, 2020Jornal de PediatriaOpen Access

Laboratory diagnosis of COVID-19

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Key Points

To synthesize literature on diagnostic methods and supportive laboratory tests for SARS-CoV-2 identification and disease prognosis.
Conducted a non-systematic search of articles indexed in PubMed and Google Scholar published during 2020 on COVID-19 diagnostic tests.
Real-time polymerase chain reaction (RT-PCR) serves as the diagnostic gold standard during the first week of symptoms, while serological testing becomes clinically informative starting in the second week.
Supportive biomarkers including C-reactive protein, D-dimer, ferritin, procalcitonin, and lactic dehydrogenase effectively indicate risks of severe disease, myocardial injury, and thromboembolic events.
RT-PCR exhibits suboptimal sensitivity, underscoring the necessity of integrating clinical presentation, epidemiological history, imaging, and prognostic blood markers for comprehensive management.

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Implication

Narrative review evaluates laboratory diagnostic methods and severity biomarkers for COVID-19, highlighting the limitations of RT-PCR sensitivity and the need for multimodal clinical assessments.

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Ekaterini Goudouris (2020) studied this question.

synapsesocial.com/papers/6aade59164f913cc7400ddc0 https://doi.org/10.1016/j.jped.2020.08.001

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Laboratory diagnosis of COVID-19

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Laboratory diagnosis of COVID-19

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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