Key result
FHL2 drives epithelial-mesenchymal transition and promotes invasion in colon cancer cells.
Why the study?
The role of four-and-a-half LIM protein 2 (FHL2) in epithelial-mesenchymal transition and invasion of colon cancer was not fully understood.
Does FHL2 promote epithelial-mesenchymal transition and invasion in colon cancer?
Does FHL2 promote epithelial-mesenchymal transition and invasion in colon cancer?
FHL2 acts as a potent inducer of epithelial-mesenchymal transition and promotes invasion in colon cancer cells, suggesting it as a potential mediator of metastasis.
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FHL2 modulation of EMT in colon cancer models leaves open its clinical relevance and therapeutic targeting.
Zhang et al. (2010) studied Colon cancer. FHL2 overexpression or depletion was evaluated on Epithelial-mesenchymal transition and invasion. Four-and-a-half LIM protein 2 (FHL2) acted as a potent epithelial-mesenchymal transition inducer and promoted invasion in colon cancer cells.
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