Key result
Potassium outward currents in rat lateral geniculate nucleus neurons exhibit diverse kinetics and voltage dependence.
Why the study?
Different classes of potassium outward currents in relay neurons of the rat lateral geniculate nucleus were characterized to understand their electrophysiological roles.
Population
Relay neurons acutely isolated from the rat lateral geniculate nucleus
Comparison
Depolarization with and without pharmacological blockers 4-AP and TEA
Design
Preclinical electrophysiological study using whole-cell patch-clamp technique
Authors
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Diverse K+ currents may tune rat LGN firing; leaves open translational relevance to human thalamocortical disorders.
Different classes of potassium outward currents in rat LGN relay neurons have distinct kinetics and pharmacological sensitivities that cooperatively control firing threshold.
Budde et al. (1992) studied this question. Potassium channel blockers (4-AP, TEA) was evaluated on Characterization of potassium outward currents. Different classes of potassium outward currents in rat lateral geniculate nucleus relay neurons exhibit a wide range of kinetics and voltage or calcium dependence.
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