Post-operative bilateral anterior uveitis: a rare case of ocular complication associated with anti-adhesion agent use in obstetric and gynaecologic surgery

Drug-induced uveitis is a rare and often under-recognised entity. We present a rare case series of bilateral anterior uveitis associated with Mediclore, a thermosensitive anti-adhesion agent composed of gelatine, chitosan, and poloxamer, used in obstetric and gynaecologic surgery. Nine female patients aged 30-51 were included; five had Caesarean sections, and four had total abdominal hysterectomy with bilateral salpingo-oophorectomy (one patient also had an appendectomy). Ocular symptoms started on the first/second postoperative day. Initial visual acuity (VA) was between 0.5 and 1.0; intraocular pressure was normal; and inflammation was mild, anterior, and frequently bilateral. Topical corticosteroids (dexamethasone, prednisolone acetate, or fluorometholone) and mydriatics were prescribed. Active infection screening was ruled out. All patients demonstrated remission with a VA of 1.0 and no persistent inflammation. Even though topical medication gave favourable results, clinicians should be aware of this potential association, ensure appropriate screening to exclude mimickers, and counsel patients accordingly.