Key result
NBUVB treatment modifies PASI scores and serum angiopoietin-2 levels linked to disease severity.
Why the study?
Angiogenesis plays an important role in psoriasis pathogenesis, and the role of angiopoietin 2 in psoriasis severity and response to NBUVB treatment was unclear.
Does narrowband ultraviolet B treatment reduce serum levels of angiopoietin-2 and improve PASI scores in patients with moderate-severe plaque psoriasis?
Cross-Sectional (n=76)
Does narrowband ultraviolet B treatment reduce serum levels of angiopoietin-2 and improve PASI scores in patients with moderate-severe plaque psoriasis?
Angiopoietin-2 levels correlate with psoriasis severity and decrease following narrowband ultraviolet B treatment, suggesting its potential utility as a biomarker.
Ang-2 may track psoriasis severity and NBUVB response; hypothesis-generating for biomarker utility, should not yet change practice.
BACKGROUND: Psoriasis is a chronic inflammatory hyper proliferative skin disease. Angiogenesis play an important role in Psoriasis pathogenesis, occurring even before plaque formation. Angiopoietins play an important role in angiogenesis and hence are described as angiogenic factors. AIMS: To evaluate serum levels of angiopoeitin 2 (Ang-2) following treatment with narrowband ultraviolet B (NBUVB) in patients with moderate-severe plaque psoriasis and correlate it to psoriasis area and severity index (PASI). PATIENTS/METHODS: This cross sectional study included 38 patients complaining of moderate to severe plaque psoriasis and 38 healthy controls. Psoriasis area and severity index (PASI) was determined and was correlated to serum levels of Ang-2 before and after treatment with NBUVB. RESULTS: PASI scores and serum values of angiopoietin 2 demonstrated a significant difference between the baseline and at the end of the 12 weeks NBUVB treatment. A statistically significant positive correlation was established between psoriasis severity and Ang-2 serum levels before and after treatment. CONCLUSION: The study demonstrated a potential contribution of Ang-2 in the pathogenesis of psoriasis, as well as its usefulness as a biomarker of psoriasis severity.
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Nada et al. (2021) conducted a cross-sectional in Moderate-severe plaque psoriasis (n=76). Narrowband ultraviolet B (NBUVB) vs. Healthy controls and baseline was evaluated on PASI scores and serum levels of angiopoietin-2. Narrowband ultraviolet B treatment for 12 weeks resulted in significant differences in PASI scores and serum angiopoietin-2 levels from baseline, which positively correlated with disease severity.
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