What question did this study set out to answer?

To evaluate circulating levels and longitudinal changes of IL-22, IL-17, IL-23, IL-8, VEGF, and TNF-α in patients with psoriasis vulgaris undergoing PUVA or narrowband UVB phototherapy.

August 17, 2010British Journal of Dermatology

Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy

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Authors

SCSusana CoimbraUniversidade do Porto HOHugo OliveiraCentro Universitário São Lucas FRFlávio ReisUniversity of Coimbra

Discussion

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Implication

Longitudinal study reveals progressive downregulation of inflammatory cytokines during phototherapy in psoriasis, indicating suppression of the IL-23/Th17 pathway.

Key Points

To evaluate circulating levels and longitudinal changes of IL-22, IL-17, IL-23, IL-8, VEGF, and TNF-α in patients with psoriasis vulgaris undergoing PUVA or narrowband UVB phototherapy.
Conducted a cross-sectional comparison with 20 healthy controls and a longitudinal cohort study of 34 patients with psoriasis vulgaris.
Assigned patients to either narrowband ultraviolet B (NB-UVB; n=17) or psoralen-ultraviolet A (PUVA; n=17) therapy.
Measured serum levels of IL-22, IL-17, IL-23, IL-8, TNF-α, and VEGF alongside PASI scores at baseline (T0), 3 weeks (T3), 6 weeks (T6), and 12 weeks (T12).
At baseline, all cytokines and growth factors except TNF-α were significantly elevated in psoriasis patients compared with healthy controls.
Both phototherapy modalities drove early reductions in TNF-α and IL-23 by week 3, followed by significant decreases in IL-22 and IL-17 by week 6.
By week 12, all cytokines and PASI scores decreased significantly, although VEGF concentrations remained significantly elevated relative to controls in both groups.

Cite This Study

Coimbra et al. (2010) studied this question.

synapsesocial.com/papers/6a8b8f97f19228bbb2fb5525 https://doi.org/10.1111/j.1365-2133.2010.09992.x

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Implication

Longitudinal study reveals progressive downregulation of inflammatory cytokines during phototherapy in psoriasis, indicating suppression of the IL-23/Th17 pathway.

Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy

Discussion

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Implication

Key Points

Cite This Study

Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy

Discussion

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Implication

Key Points

Cite This Study

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