Complete Response in Patient with Metastatic Breast Cancer Treated with Metronomic Chemotherapy

Background: Here we report a case of complete response in patient with Metastatic Breast Cancer treated by metronomic Chemotherapy.Case presentation: A 51 years old woman underwent righy mastectomy in may 2008.She performed firstline chemotherapy with doxorubicin every 21 days.The CT revaluation after ten cycle showed a partial response to treatment.It was decided to stop the treatment with doxorubicin and to start a metronomic therapy with cyclophosphamide 50 mg daily orally and Methotrexate 2.5 mg twice daily.After two months of this maintenance treatment, the CT scan showed a complete response.The metronomic treatment is still ongoing, and after 45 months the patient maintains a complete response. Conclusion:This clinical case also highlights how suitable metronomic chemotherapy can be as maintenance therapy, allowing long-term treatment with no relevant toxicity.