Key result
Doxorubicin, daunorubicin, and epirubicin remain stable for at least 43 days in cold storage.
Why the study?
The stability of doxorubicin, daunorubicin, and epirubicin in infusion fluids stored in plastic syringes and minibags under various conditions was not well characterized.
Doxorubicin, daunorubicin, and epirubicin demonstrate prolonged stability when stored in PVC minibags or polypropylene syringes under refrigerated or frozen conditions.
May inform extended anthracycline storage in pharmacy; leaves open clinical validation before practice change.
The shelf lives of doxorubicin, daunorubicin and epirubicin in infusion fluids were studied using high-performance liquid chromatographic (HPLC) methods. Doxorubicin and epirubicin were stable (loss in potency of less than 10%) for 24 and 20 days respectively, when dissolved in sodium chloride solution (0.9%; pH, 6.47) at 25 degrees C and stored in polyvinyl chloride (PVC) minibags, while daunorubicin was stable for at least 43 days. All three drugs were stable for at least 43 days in sodium chloride (0.9%; pH 6.47 and 5.20) and dextrose (5%; pH 4.36) at 4 and -20 degrees C. Repeated thawing and re-freezing of these solutions at ambient temperature did not cause degradation. All three drugs were stable for at least 43 days when reconstituted with Water-for-Injections BP and stored in polypropylene syringes at 4 degrees C.
No takes yet. Share an insight, caveat, or question.
Wood et al. (1990) studied this question. Doxorubicin, daunorubicin, and epirubicin was evaluated on Stability (loss in potency of less than 10%). Doxorubicin, daunorubicin, and epirubicin remained stable for at least 43 days when stored in sodium chloride or dextrose at 4 and -20 degrees C, and in polypropylene syringes at 4 degrees C.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: