Key result
CD36 rs1049673 C allele linked to increased premature CHD risk.
Why the study?
Risk factors for premature coronary heart disease in Chinese Han patients and their association with CD36 polymorphisms at rs1049673, rs7755, and rs321159 were investigated.
Are CD36 polymorphisms associated with premature coronary heart disease in Chinese Han patients?
Case-Control (n=135)
Are CD36 polymorphisms associated with premature coronary heart disease in Chinese Han patients?
The rs1049673 polymorphism in CD36, along with traditional risk factors, is significantly associated with premature coronary heart disease in Chinese Han patients.
May support risk assessment in Chinese Han patients; leaves open prospective validation and causality.
Risk factors for premature coronary heart disease in China can be multiple; we investigated Chinese Han patients with premature coronary heart disease and a possible association with CD36 polymorphism at rs1049673, rs7755, and rs321159 sites. Outpatients were recruited according to chest X-ray coronary arteriography results; they were divided into two groups: early coronary artery lesions (premature coronary heart disease group, test group) and a control group. Coronary arteriography and laboratory blood examinations were conducted to analyze risk factors for coronary heart disease and CD36 polymorphisms. Seventy nine test and 56 control group patients were recruited. Compared with the control, the test groups had a significantly higher proportion of male patients, smoking, diabetes and metabolic syndromes, significantly higher levels of TG, LDL-C, ox-LDL, WBC, UA, FBG, and significantly lower levels of HDL-C. For rs1049673, rs7755, and rs321159 sites, patients with premature coronary heart disease have family genetic predisposition at high LDL-C level with GA, AA, and TT genotypes. Unconditional logistic regression analysis showed that gender, diabetes, high TG, LDL-C level and C carriers of rs1049673 significantly affected risk for premature coronary heart disease.
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Che et al. (2014) conducted a case-control in Premature coronary heart disease (n=135). CD36 polymorphism (rs1049673, rs7755, rs321159) vs. Control group (without premature coronary heart disease) was evaluated on Risk for premature coronary heart disease. C carriers of the rs1049673 polymorphism in CD36, along with male gender, diabetes, high TG, and high LDL-C, were significantly associated with an increased risk of premature coronary heart disease.
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