Key result
[18F]DOPA PET/CT scanning enables limited excision and complete cure of focal congenital hyperinsulinism.
Why the study?
Histological differentiation of congenital hyperinsulinism into focal and diffuse disease has radically changed surgical management, requiring correct localisation of focal lesions.
[18F]DOPA PET/CT scan can help localize focal lesions in congenital hyperinsulinism to guide surgical excision.
May guide focal lesion excision in congenital hyperinsulinism; hypothesis-generating and requires prospective validation before wider use.
Congenital hyperinsulinism (CHI) is a cause of severe hypoglycaemia in the neonatal period.1 The histological differentiation of CHI into focal and diffuse disease has radically changed the surgical management of patients with the disease.2 Correct localisation and limited excision of the focal lesion results in complete cure of the patient. Recent advances …
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Kapoor et al. (2008) studied this question. [18F]DOPA PET/CT scanning for correct localization and limited excision of focal lesions in congenital hyperinsulinism results in complete cure of the patient.
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