Key result
Amniotic fluid sTREM-1 predicts subclinical chorioamnionitis with ~82% sensitivity in premature rupture of membranes.
Why the study?
Premature rupture of membranes frequently occurs with concomitant chorioamnionitis, and the study aimed to evaluate sTREM-1 levels as potential indicators compared to standard laboratory markers.
Do serum and amniotic fluid sTREM-1 levels improve the prediction of subclinical chorioamnionitis compared to WBC count and CRP in pregnant women with premature rupture of membranes?
Cross-Sectional (n=55)
No
Do serum and amniotic fluid sTREM-1 levels improve the prediction of subclinical chorioamnionitis compared to WBC count and CRP in pregnant women with premature rupture of membranes?
Effect estimate: AUC 0.865 (95% CI 0.764-0.966)
p-value: p=<0.001
Serum and amniotic fluid sTREM-1 levels are superior to WBC count for the early prediction of subclinical chorioamnionitis in pregnant women with premature rupture of membranes.
sTREM-1 may aid early detection of subclinical chorioamnionitis in PROM; leaves open clinical adoption pending larger prospective studies.
Premature rupture of membranes (PROM) is a common obstetric complication frequently occurring with concomitant chorioamnionitis. The present study aimed to evaluate levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in serum and amniotic fluid in pregnant women with PROM and to compare sTREM-1 with the commonly used laboratory indicators, serum C-reactive protein (CRP) and white blood cell (WBC) count. A total of 55 pregnant women with PROM were enrolled. Their venous blood and amniotic fluid were collected at delivery. sTREM-1 concentrations in the serum and amniotic fluid were determined by enzyme-linked immunosorbent assay. The measured data were compared with the pathological results of the placenta and fetal membrane. Meanwhile, sTREM-1 was compared with the laboratory indicators, serum CRP and WBC count. Serum and amniotic fluid sTREM-1 levels were significantly higher in pregnant women with subclinical chorioamnionitis compared to pregnant women without chorioamnionitis. Serum concentration of sTREM-1 yielded a sensitivity of 81.8% and a specificity of 77.3% for the prediction of subclinical chorioamnionitis. The amniotic fluid concentration of sTREM-1 resulted in a sensitivity of 81.8% and a specificity of 86.4% for the prediction of subclinical chorioamnionitis. In conclusion, serum and amniotic fluid sTREM-1 levels may emerge as early biological indicators for predicting PROM complicated with subclinical chorioamnionitis. sTREM-1 levels are superior to WBC count in predicting subclinical chorioamnionitis.
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A 2011 study conducted a cross-sectional in Premature rupture of membranes and subclinical chorioamnionitis (n=55). Amniotic fluid and serum sTREM-1 levels vs. White blood cell count and serum C-reactive protein was evaluated on Prediction of subclinical chorioamnionitis using amniotic fluid sTREM-1 (AUC 0.865, 95% CI 0.764-0.966, p=<0.001). Amniotic fluid sTREM-1 levels predicted subclinical chorioamnionitis in pregnant women with premature rupture of membranes with an AUC of 0.865, a sensitivity of 81.8%, and a specificity of 86.4%.
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