Key result
Epidemiologic twin and family studies link genetics to stroke risk.
Why the study?
Understanding the genetic mechanisms underlying stroke is essential to improve prevention and treatment strategies for this leading cause of death and disability.
This article reviews the pathophysiological mechanisms and genetic influences underlying ischemic and hemorrhagic stroke.
Answers are grounded in this paper and cite their sources.
Highlights multiple stroke mechanisms; leaves open targeted interventions until validated in trials.
Stroke is the second leading cause of death and the most common cause of disability in the world. Its incidence is rising with increasing life expectancy. To relieve the heavy burden of stroke, we need to understand the mechanisms that will form the basis of improved prevention and treatment. Ischemic or hemorrhagic stroke is the outcome of a number of different pathophysiological mechanisms, which include cardioembolism, prothrombotic states, and disease of large and small cerebral vessels. Epidemiologic studies involving twins, siblings, or families have found evidence of a genetic influence on stroke. From the clinical point of view, it is . . .
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Elisabeth Tournier‐Lasserve (2002) conducted a review in Stroke. Genetics was evaluated. Epidemiologic studies involving twins, siblings, or families have found evidence of a genetic influence on stroke.
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