Key result
Chronic rejection limits 5-year survival after lung transplantation to ~50%.
Why the study?
Chronic rejection as obliterative bronchiolitis/bronchiolitis obliterans syndrome limits 5-year survival after lung transplantation, necessitating better understanding of its mechanisms.
Population
Lung transplant recipients
Design
Review of recent immunobiology advances
Authors
Loading...
Advances in OB/BOS may improve lung transplant survival; leaves open prospective validation before practice change.
This review summarizes recent advances in the immunobiology and mechanisms of chronic lung allograft dysfunction, a major cause of long-term mortality in lung transplant recipients.
Shilling et al. (2009) conducted a review in Chronic Lung Allograft Dysfunction (Obliterative Bronchiolitis/Bronchiolitis Obliterans Syndrome). Chronic rejection, known as obliterative bronchiolitis or bronchiolitis obliterans syndrome, limits 5-year survival after lung transplantation to approximately 50%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: