What question did this study set out to answer?

To evaluate the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and serious, acute non-infectious liver injury.

October 10, 1992BMJOpen Access

The role of non-steroidal anti-inflammatory drugs in acute liver injury.

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Authors

LRL. A. Garcia RodriguezCentro Español de Investigación Farmacoepidemiológica AWA M WalkerUniversity of California, Riverside LLLeah LueckCharité - Universitätsmedizin Berlin

Discussion

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Implication

Retrospective cohort study reveals increased risk of acute liver injury in adults taking non-steroidal anti-inflammatory drugs, indicating a small absolute excess risk.

Key Points

To evaluate the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and serious, acute non-infectious liver injury.
Conducted a retrospective cohort study using a crossover design with provincial health database records from Saskatchewan, Canada (1982–1986).
Analyzed N=228,392 adults contributing 645,456 person-years who were current or past users of non-steroidal anti-inflammatory drugs.
Tracked NSAID prescriptions and identified hospital admissions for newly diagnosed acute non-infectious liver injury.
Identified 34 hospital admissions for acute liver injury, yielding an incidence rate of 9 per 100,000 person-years (95% CI, 6 to 15) among current NSAID users.
Current NSAID use showed an unadjusted rate ratio of 2.3 (95% CI, 1.1 to 4.9) and an age- and sex-adjusted rate ratio of 1.7 (95% CI, 0.8 to 3.7), corresponding to an excess risk of 5 per 100,000 person-years.
Excluding patients with concomitant hepatotoxic drug use yielded a rate ratio of 4.0 (95% CI, 0.9 to 19.0), whereas prolonged treatment duration showed no increased risk (rate ratio 1.0; 95% CI, 0.3 to 3.5).

Cite This Study

Rodriguez et al. (1992) studied this question.

synapsesocial.com/papers/6aadf2076136eb18dc873c22 https://doi.org/10.1136/bmj.305.6858.865

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October 10, 1992BMJOpen Access

The role of non-steroidal anti-inflammatory drugs in acute liver injury.

View Full Paper

Ask AI

Bookmark

Authors

LRL. A. Garcia RodriguezCentro Español de Investigación Farmacoepidemiológica AWA M WalkerUniversity of California, Riverside LLLeah LueckCharité - Universitätsmedizin Berlin

Discussion

Member takes

Implication

Retrospective cohort study reveals increased risk of acute liver injury in adults taking non-steroidal anti-inflammatory drugs, indicating a small absolute excess risk.

Key Points

To evaluate the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and serious, acute non-infectious liver injury.
Conducted a retrospective cohort study using a crossover design with provincial health database records from Saskatchewan, Canada (1982–1986).
Analyzed N=228,392 adults contributing 645,456 person-years who were current or past users of non-steroidal anti-inflammatory drugs.
Tracked NSAID prescriptions and identified hospital admissions for newly diagnosed acute non-infectious liver injury.
Identified 34 hospital admissions for acute liver injury, yielding an incidence rate of 9 per 100,000 person-years (95% CI, 6 to 15) among current NSAID users.
Current NSAID use showed an unadjusted rate ratio of 2.3 (95% CI, 1.1 to 4.9) and an age- and sex-adjusted rate ratio of 1.7 (95% CI, 0.8 to 3.7), corresponding to an excess risk of 5 per 100,000 person-years.
Excluding patients with concomitant hepatotoxic drug use yielded a rate ratio of 4.0 (95% CI, 0.9 to 19.0), whereas prolonged treatment duration showed no increased risk (rate ratio 1.0; 95% CI, 0.3 to 3.5).

Cite This Study

Rodriguez et al. (1992) studied this question.

synapsesocial.com/papers/6aadf2076136eb18dc873c22 https://doi.org/10.1136/bmj.305.6858.865

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