Key result
Cardiopulmonary bypass impairs organ function and causes fluid retention via blood contact with synthetic surfaces.
Why the study?
Much of the morbidity associated with open heart surgery is due to the effects of cardiopulmonary bypass on homeostasis and organ function.
Answers are grounded in this paper and cite their sources.
Cardiopulmonary bypass causes profound systemic physiological disruptions, including organ impairment and fluid retention, which contribute significantly to surgical morbidity.
Cardiopulmonary bypass makes a mess of homeostasis. Extracorporeal perfusion produces pulseless flow without physiologic controls, showers microemboli throughout the body, and brings blood diluted with additives to an enzymatic boil. Much of the morbidity associated with open heart surgery is due to contact of blood with the synthetic surfaces of the extracorporeal perfusion circuit. Bypass temporarily impairs function of every organ, alters concentrations of over 25 vasoactive substances within the plasma, and causes massive retention of fluid. In short, cardiopulmonary bypass makes patients sick.
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L. Henry Edmunds (1993) conducted a review in Open heart surgery. Cardiopulmonary bypass was evaluated. Cardiopulmonary bypass impairs organ function, alters vasoactive substances, and causes fluid retention due to blood contact with synthetic surfaces.
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