Key result
Pre-operative moderate or worse PH is linked to ~25-fold higher early mortality alongside prolonged CPB time.
Why the study?
Outcomes of biventricular repair for double outlet right ventricle and postoperative risk factors for mortality and late intervention in developing countries were not well reported.
What are the outcomes and risk factors for mortality and late intervention following biventricular repair in patients with double outlet right ventricle?
Cohort (n=96)
No
What are the outcomes and risk factors for mortality and late intervention following biventricular repair in patients with double outlet right ventricle?
Odds Ratio: 24.558
p-value: p=0.023
Prolonged cardiopulmonary bypass time and pre-operative moderate or severe pulmonary hypertension are independent risk factors for early mortality after biventricular repair for double outlet right ventricle.
May warrant heightened perioperative vigilance for moderate pulmonary hypertension; leaves open prospective validation in congenital heart surgery.
Objectives: The purpose of this study was to report outcomes of double outlet right ventricle biventricular repair at a single institution in developing countries and to investigate post-operatively determined risk factors for mortality and late intervention. Methods: Patients with double outlet right ventricle who underwent biventricular repair in our centre from January 2009 to December 2021 were included. Results: A total of 96 patients (male/female = 61/35) with biventricular repair were included. According to its specific anatomical type, the appropriate individual surgical plan was selected. Multivariate analysis indicated that prolonged cardiopulmonary bypass time(OR = 1.044; p = 0.012) and pre-operative moderate or above pulmonary hypertension(OR = 24.558; p = 0.023) were independent risk factors for early mortality. Univariate analysis showed that different anatomical types and different surgical methods had similar late intervention and late mortality. Concomitant coarctation of the aorta(OR = 40; p = 0.020) and concomitant ventricular septal defect enlargement(OR = 26.667; p = 0.005) were independent risk factors for late intervention by multivariate analysis. Conclusion: Selection of appropriate surgical techniques based on different anatomical types often results in similar late outcomes. For patients with concomitant ventricular septal defect enlargement during the operation, it is necessary to fully expand and avoid damage to the conduction bundle. We should timely intervention in patients with coarctation of the aorta and pay attention to the occurrence of left ventricular outflow tract obstruction during follow-up.
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Wang et al. (2022) conducted a cohort in Double outlet right ventricle (n=96). Pre-operative moderate or above pulmonary hypertension vs. No or mild pulmonary hypertension was evaluated on Early mortality (OR 24.558, p=0.023). Pre-operative moderate or above pulmonary hypertension (OR 24.558, p=0.023) and prolonged cardiopulmonary bypass time (OR 1.044, p=0.012) were independent risk factors for early mortality.
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