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The comorbidity of obsessive-compulsive symptoms (OCS) and schizophrenia has been documented by epidemiological investigations [ 2 ] [ 9 ] [ 12 ]. OCS is thought to markedly increase the risk of suicides in schizophrenia [ 11 ]. Within the multiple pathogenetic factors leading to OCS in schizophrenic patients, treatment with atypical antipsychotics such as clozapine has been discussed for a significant subgroup of these patients [ 6 ] [ 10 ]. Here, we report the improvement of clozapine-induced OCS after dose reduction to minimal sufficient levels facilitated by augmentation with valproic acid.
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Zink et al. (2007) studied this question.
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