Key result
Increasing age in children is linked to greater pulse pressure amplification averaging ~4.5 mmHg.
Why the study?
Pulse pressure amplification has been examined in adults but not in children, leaving a gap in understanding its characteristics during childhood.
Cross-Sectional (n=54)
Pulse pressure amplification is present in children and its degree increases with age, contrary to the pattern seen in adults.
Answers are grounded in this paper and cite their sources.
Challenges adult-centric pulse pressure models; extends pediatric vascular data but remains hypothesis-generating without longitudinal outcomes.
INTRODUCTION: A peripheral pulse pressure (PP) is larger than a central PP (PP amplification). The phenomenon has been examined in adult, but not in children. METHODS: Fifty-four patients with a normal aorta were enrolled. The ascending and descending aorta pressure waveforms were recorded by a pressure sensor-mounted catheter. The difference of the PP, which was defined as the PP in the descending aorta minus that in the ascending aorta and the ratio of the PP, which was defined as the ratio of the descending to the ascending aortic PP, was examined as the index of the PP amplification. RESULTS: The patient's age was 6.2 ± 3.0 years. The difference of the PP was 4.5 ± 2.7 mmHg and had a significant positive relationship with the mean blood pressure (r = 0.46, P = 0.0005) and the age (r = 0.36, P = 0.009). The ratio of the PP was 1.14 ± 0.08 and had a significant positive relationship with the mean blood pressure (r = 0.42, P = 0.002) and the age (r = 0.29, P = 0.04). CONCLUSION: The PP amplification is observed even in children. The degree of the PP amplification increases with age during childhood contrary to the relationship in adults.
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Murakami et al. (2017) conducted a cross-sectional in Normal aorta (n=54). Age and mean blood pressure was evaluated on Pulse pressure amplification (difference and ratio of descending to ascending aortic PP) (r = 0.36, p=0.009). Pulse pressure amplification is present in children (mean difference 4.5 ± 2.7 mmHg) and its degree increases significantly with age (r = 0.36, P=0.009).
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