Key result
Higher augmentation index (OR 1.27; 95% CI 1.09-1.48) and systemic vascular resistance were independently associated with higher odds for low pulse pressure amplification in drug-naïve hypertensives.
Why the study?
The relative importance of parameters modulating aortic-to-brachial pulse pressure amplification as hemodynamic determinants remained elusive.
Population
88 consecutive drug-naïve hypertensives
Comparison
Tertiles according to the magnitude of PP amplification
Design
Cross-sectional study
Authors
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Wave reflections and resistance outweigh stiffness as PP amplification determinants in untreated hypertension; hypothesis-generating for targeted interventions pending prospective validation.
Cross-Sectional (n=88)
Odds Ratio: 1.27 (95% CI 1.09–1.48)
In newly-diagnosed drug-naïve hypertensives, elevated wave reflections and systemic vascular resistance are stronger determinants of pulse pressure amplification than aortic stiffness.
Papakonstantinou et al. (2019) conducted a cross-sectional in Hypertension (n=88). Higher augmentation index (AIx) vs. Lower augmentation index was evaluated on Low pulse pressure (PP) amplification (OR 1.27, 95% CI 1.09-1.48). Higher augmentation index (OR 1.27; 95% CI 1.09-1.48) and systemic vascular resistance were independently associated with higher odds for low pulse pressure amplification in drug-naïve hypertensives.
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