Transfer function-derived central pressure and cardiovascular disease events
Key result
Among 2,183 participants (6.8% event rate), central hemodynamics derived via radial artery tonometry were not predictive of major CVD events beyond standard risk factors (P=0.20 for central SBP).
Why the study?
Do central hemodynamics derived from radial artery tonometry predict first-onset major CVD events beyond standard risk factors including brachial SBP?
Population
2183 participants in the Framingham Heart Study, mean age 62 years, 58% women.
Comparison
Central hemodynamics evaluated using radial… vs Standard risk factors including brachial cuff…
Design
Cohort
Follow-up
median 7.8 (limits 0.2-8.9) years
Authors
Discussion
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Implication
Central hemodynamics via tonometry should not guide CVD risk stratification; leaves open value in other cohorts or refined models.
Study Design
Type
Cohort (n=2,183)
Structured PICO
Do central hemodynamics derived from radial artery tonometry predict first-onset major CVD events beyond standard risk factors including brachial SBP?
P
Population
2,183 participants (mean age 62 years, 58% women) in the Framingham Heart Study followed for a median of 7.8 years for first-onset major CVD events.
E
Exposure
Central hemodynamics (augmentation index, central SBP, central PP, and central-to-peripheral PP amplification) evaluated using radial artery tonometry and a generalized transfer function (SphygmoCor device)
C
Comparator
Standard risk factors including brachial cuff systolic blood pressure
O
Outcome
First-onset major cardiovascular disease (CVD) eventshard clinical
Main Result
p-value: p=0.20
Central hemodynamics derived from radial artery tonometry and a generalized transfer function do not improve cardiovascular disease risk prediction beyond standard risk factors including brachial systolic blood pressure.
Cite This Study
Mitchell et al. (2016) conducted a cohort in Cardiovascular disease (n=2,183). Central hemodynamics derived using radial artery tonometry vs. Standard risk factors including brachial cuff SBP was evaluated on First-onset major CVD events (p=0.20). Among 2,183 participants (6.8% event rate), central hemodynamics derived via radial artery tonometry were not predictive of major CVD events beyond standard risk factors (P=0.20 for central SBP).