Key result
Systolic ECG-gated 3D SSFP yields ~3 mm larger RVOT effective diameter compared to ceMRA.
Why the study?
Accurate assessment of RVOT dimensions prior to PPVI in patients after TOF repair requires comparison of imaging modalities to identify the optimal measurement technique.
Does ECG-gated 3D SSFP improve RVOT sizing accuracy compared to ceMRA in patients considered for PPVI after TOF repair?
Observational (n=89)
No
Does ECG-gated 3D SSFP improve RVOT sizing accuracy compared to ceMRA in patients considered for PPVI after TOF repair?
Absolute Event Rate: 27.4% vs 24.4%
p-value: p=<0.0001
ECG-gated 3D SSFP in systole allows precise sizing of the RVOT for PPVI, showing excellent correlation with invasive balloon sizing and better reproducibility than non-gated ceMRA.
May support systolic SSFP for dynamic RVOT assessment in PPVI candidates; leaves open whether it improves selection or outcomes versus ceMRA.
To compare contrast-enhanced magnetic resonance angiography (ceMRA) and 3D steady-state free precession (SSFP) during systole and diastole for assessment of the right ventricle outflow tract (RVOT) in patients considered for percutaneous pulmonary valve implantation (PPVI) after tetralogy of Fallot (TOF) repair. We retrospectively evaluated 89 patients (male: 45, mean age 19 ± 8 years), who underwent cardiac-MRI after surgical TOF-repair. Datasets covering the whole heart in systole and diastole were acquired using ECG-gated 3D SSFP and non-gated ceMRA. Measurements were performed in SSFP-sequences and in ceMRA in the narrowest region of the RVOT to obtain the minimum, maximum and effective diameter. Invasive balloon sizing as the gold standard was available in 12 patients. The minimum diameter in diastolic SSFP, systolic SSFP and ceMRA were 21.4 mm (± 6.1 mm), 22.6 mm (± 6.2 mm) and 22.6 mm (± 6.0 mm), respectively. Maximum diameter was 29.9 mm (± 9.5 mm), 30.0 mm (± 7.0 mm) and 28.8 mm (± 8.1 mm) respectively. The effective diameter was 23.2 mm (± 5.7 mm), 27.4 mm (± 6.7 mm) and 24.4 mm (± 6.2 mm), differing significantly between diastole and systole (p < 0.0001). Measurements in ECG-gated SSFP showed a better inter- and intraobserver variability compared to measurements in non-ECG-gated ceMRA. Comparing invasive balloon sizing with our analysis, we found the highest correlation coefficients for the maximum and effective diameter measured in systolic SSFP (R = 0.99 respectively). ECG-gated 3D SSFP enables the identification and characterization of a potential landing zone for PPVI. The maximum and effective systolic diameter allow precise sizing for PPVI. Patients with TOF-repair could benefit from cardiac MRI before PPVI.
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Ebel et al. (2019) conducted an observational in Tetralogy of Fallot (TOF) repair (n=89). 3D steady-state free precession (SSFP) MRI vs. Contrast-enhanced magnetic resonance angiography (ceMRA) was evaluated on Effective diameter of the right ventricle outflow tract (RVOT) (p=<0.0001). ECG-gated 3D steady-state free precession during systole yielded a significantly larger effective diameter of the right ventricular outflow tract (27.4 mm) compared to diastole (23.2 mm) and ceMRA (24.4 mm).
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