What question did this study set out to answer?

To refine the genomic map of a major quantitative trait locus on bovine chromosome 20 and identify the specific causal mutation altering milk yield and composition.

January 1, 2003Genetics

Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition

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Authors

SBSarah BlottUniversity of Nottingham JKJong-Joo KimYeungnam University SMSirja MoisioUniversity of Auckland

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Implication

Genetic mapping reveals a growth hormone receptor mutation affecting milk yield and composition in dairy cattle, indicating a key causal variant for livestock production.

Key Points

To refine the genomic map of a major quantitative trait locus on bovine chromosome 20 and identify the specific causal mutation altering milk yield and composition.
Constructed a high-density genetic marker map spanning bovine chromosome 20.
Evaluated linkage disequilibrium across the target region using two complementary mapping strategies.
Sequenced candidate genomic regions, specifically the growth hormone receptor gene, in cattle of known quantitative trait locus genotype.
Mapped the chromosome 20 quantitative trait locus effect to a genomic segment containing the growth hormone receptor gene.
Identified a phenylalanine-to-tyrosine substitution in the transmembrane domain of the growth hormone receptor.
Demonstrated that the amino acid substitution is strongly associated with milk yield and milk composition in the general cattle population.

Cite This Study

Blott et al. (2003) studied this question.

synapsesocial.com/papers/6aadf92a3a629674b6b32af3 https://doi.org/10.1093/genetics/163.1.253

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Implication

Genetic mapping reveals a growth hormone receptor mutation affecting milk yield and composition in dairy cattle, indicating a key causal variant for livestock production.

Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition

Discussion

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Implication

Key Points

Cite This Study

Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition

Discussion

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Implication

Key Points

Cite This Study

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