Key result
Passiflora incarnata extract prevents dyslipidemia and LVH in mice fed a high-fat diet.
Why the study?
The control of dyslipidemia using herbal products and their effects on cardiac and hepatic oxidative stress require evaluation in preclinical models.
Does Passiflora incarnata L. dry extract improve dyslipidemia and prevent left ventricular hypertrophy and hepatic oxidative stress in LDLr-/- mice fed a high-fat diet?
Does Passiflora incarnata L. dry extract improve dyslipidemia and prevent left ventricular hypertrophy and hepatic oxidative stress in LDLr-/- mice fed a high-fat diet?
Passiflora incarnata L. dry extract prevents dyslipidemia, hepatic oxidative stress, and left ventricular hypertrophy in a mouse model of high-fat diet-induced dyslipidemia.
Hypothesis-generating in LDLr-/- mice; human trials required before any clinical consideration.
The control of dyslipidemia by using herbal products is an important subject for studies. In this study, we evaluated the effects of dry Passiflora incarnata L. extract over dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress of LDL receptor knockout mice (LDLr-/-). Forty 4-month old male LDLr-/- mice were distributed into four groups: Group standard diet; Group standard diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract; Group high-fat diet; Group high-fat diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract. After 30 days, Passiflora incarnata L. dry extract reduced the effects of the high-fat diet, with a decrease of total cholesterol, triglycerides, and increase of high-density lipoprotein (HDL), as well as a reduction of C-reactive protein, alkaline phosphatase and insulin. There was no effect on glucose, Homa index and enzymes aspartate aminotransferase and alanine aminotransferase. However, the prevention of left ventricular hypertrophy occurred, as well as lipid peroxidation and the production of carbonyl proteins, which are both oxidative stress markers. In conclusion, Passiflora incarnata L. dry extract acts in the prevention of dyslipidemia, consequently, hindering the occurrence of hepatic oxidative stress and the development of left ventricular hypertrophy by the increase of serum HDL, in mice that had the effects of a high-fat diet.
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Sarto et al. (2018) studied Dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress (n=40). Dry Passiflora incarnata L. leaf extract vs. Standard diet or high-fat diet without extract was evaluated on Total cholesterol, triglycerides, HDL, C-reactive protein, alkaline phosphatase, insulin, left ventricular hypertrophy, and oxidative stress markers. Passiflora incarnata L. dry extract prevented dyslipidemia, hepatic oxidative stress, and left ventricular hypertrophy in LDLr-/- mice fed a high-fat diet.
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