Key result
Planar glass chips enable high-resolution single ion channel and whole-cell current recordings in mammalian cells.
Why the study?
Microstructuring processes for glass substrates are less well established than those for silicon-based substrates for planar patch clamp devices.
Planar glass chip devices with microstructured apertures offer a cost-effective and optically neutral alternative to silicon-based substrates for high-resolution patch clamp and simultaneous single-molecule fluorescence recordings.
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Glass chips enable scalable high-resolution patch-clamp recordings; leaves open validation in native cardiomyocytes and integrated fluorescence applications.
Fertig et al. (2003) studied this question. Planar glass chip devices with microstructured apertures was evaluated. Planar glass chip devices with micron-sized apertures produced via ion-track etching enabled high-resolution single ion channel and whole-cell current recordings from mammalian cell lines.
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