Key result
Ramipril prevents cyclosporine A-induced vascular toxicity and normalizes endothelial relaxation in isolated rat aortas.
Why the study?
The study aimed to determine whether chronic ACE inhibition prevents cyclosporine A-induced vascular toxicity.
p-value: p=<0.05
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Potentiates endothelial relaxation in rat aortas without altering contractility; leaves open ACE inhibition for cyclosporine vascular toxicity in humans.
Berkenboom et al. (1994) studied Cyclosporine A-induced vascular toxicity. Ramipril vs. Cyclosporine A alone and untreated control was evaluated on Endothelium-dependent relaxations to acetylcholine (AUC) (p=<0.05). Chronic inhibition of ACE with ramipril prevented cyclosporine A-induced vascular toxicity in isolated rat aortas, normalizing acetylcholine-induced relaxations.
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