Complications of transvenous right ventricular endomyocardial biopsy in adult patients with cardiomyopathy: A seven-year survey of 546 consecutive diagnostic procedures in a tertiary referral center
Key result
Right ventricular endomyocardial biopsy carries a 6% complication rate in adults with cardiomyopathy.
- n=464
Authors
Discussion
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Implication
Prospective cohort study finds a 6% complication rate during right ventricular endomyocardial biopsy in cardiomyopathy, indicating low overall risk but potential for mortality.
Key Points
- To determine the incidence, nature, and subsequent management of complications occurring during transvenous right ventricular endomyocardial biopsy in adult patients with cardiomyopathy.
- Prospective cohort survey analyzing 546 consecutive diagnostic procedures performed in 464 adult patients over seven years at a tertiary referral center.
- The internal jugular vein served as the primary catheter introduction site in 96% of the procedures.
- Overall complications occurred in 6.0% of procedures (33/546), including catheter insertion events in 2.7% (15/546; 12 arterial punctures, 2 vasovagal reactions, 1 prolonged bleeding) and biopsy events in 3.3% (18/546).
- Biopsy-related complications included arrhythmias in 1.1% (6/546), conduction abnormalities in 1.0% (5/546), suspected perforation in 0.7% (4/546), and definite perforation with pericardial fluid in 0.5% (3/546), leading to 2 deaths (0.4%).
- No secular trend in complication rates was observed, and events showed no association with specific clinical or hemodynamic characteristics.
Study Design
Type
Observational (n=464)
Multicenter
No
PICO
P
Population
464 consecutive adult patients with cardiomyopathy undergoing 546 right ventricular endomyocardial biopsy procedures over seven years.
E
Exposure / Comparator
Right ventricular endomyocardial biopsy
O
Primary Outcome
Incidence of complications
Cite This Study
Deckers et al. (1992) conducted an observational in Cardiomyopathy (n=464). Right ventricular endomyocardial biopsy was evaluated on Incidence of complications. Right ventricular endomyocardial biopsy in adult patients with cardiomyopathy had an overall complication rate of 6%, with a 0.4% mortality rate due to perforation.