Key result
Allosteric modulation of ion channels offers potential advantages over orthosteric ligands for treating channelopathies.
Why the study?
Ion channels are promising drug targets, but the therapeutic advantages and mechanisms of allosteric modulators in channelopathies require comprehensive review.
This review highlights the potential of allosteric modulators of ion channels as a promising and innovative approach for developing novel therapeutics for channelopathies.
No takes yet. Share an insight, caveat, or question.
May expand channelopathy options beyond orthosteric ligands; leaves open clinical validation of allosteric modulators.
Zhang et al. (2020) conducted a review in Channelopathies. Allosteric modulators vs. Orthosteric ligands was evaluated. Allosteric modulation of ligand-gated and voltage-gated ion channels represents an innovative targeting approach for treating channelopathies, offering potential advantages over orthosteric ligands.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: