Key result
Depressive symptoms in schizophrenia correlate with lower prefrontal and temporal activity during verbal fluency tasks.
Why the study?
Depressive symptoms are common and often untreated in patients with schizophrenia and are linked to poor clinical outcomes, but their association with fronto-temporal brain activities during cognitive tasks is unclear.
Are depressive symptoms associated with altered fronto-temporal activities during a verbal fluency task in patients with schizophrenia?
Cross-Sectional (n=41)
No
Are depressive symptoms associated with altered fronto-temporal activities during a verbal fluency task in patients with schizophrenia?
Reduced fronto-temporal activities on NIRS during a verbal fluency task are related to depressive symptom severity in patients with schizophrenia.
Answers are grounded in this paper and cite their sources.
Should not yet guide clinical assessment of depression in schizophrenia; leaves open whether fronto-temporal hypoactivity during verbal fluency tasks contributes to symptoms.
Though depressive symptoms are common in patients with schizophrenia, they are often left untreated and are associated with a high relapse rate, suicidal ideation, increased mortality, reduced social adjustment, and poor quality of life. The present study aims to elucidate the association between depressive symptoms and fronto-temporal activities during a cognitive task in patients with schizophrenia. The fronto-temporal activities of 41 Japanese patients with schizophrenia was evaluated during a verbal fluency task using 52-channel near-infrared spectroscopy (NIRS). Depressive symptoms were assessed using the depression/anxiety component of the Positive and Negative Syndrome Scale (PANSS) five-factor model. The depression/anxiety component of the PANSS five-factor model was negatively correlated with activities of the ventrolateral prefrontal cortex (PFC), right dorsolateral PFC, and left temporal regions. Our findings suggest that reduced fronto-temporal activities on NIRS during a verbal fluency task is related to depressive symptom severity in patients with schizophrenia.
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Pu et al. (2016) conducted a cross-sectional in Schizophrenia (n=41). Depressive symptoms (PANSS depression/anxiety component) was evaluated on Correlation between mean oxy-Hb changes during a verbal fluency task and depression/anxiety component scores of the PANSS (rho: -0.48 to -0.43, p=<0.05). Depressive symptoms in schizophrenia were negatively correlated with activities of the ventrolateral prefrontal cortex, right dorsolateral prefrontal cortex, and left temporal regions during a verbal fluency task.
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