Key result
Surgery followed by chemoradiotherapy treats primary Ewing sarcoma of the sphenoid bone in a 17-year-old.
Why the study?
Ewing sarcoma of the skull base, particularly in the sphenoid bone area, is exceedingly rare and presents challenges due to high invasion potential and difficult surgical access.
Case Report (n=1)
Ewing sarcoma of the sphenoid bone is an exceedingly rare and highly invasive tumor where surgery remains the main treatment option.
Supports feasibility of surgery plus chemoradiotherapy in rare invasive sphenoid Ewing sarcoma; leaves open need for prospective outcome data.
We performed retrospective analysis of publications describing cases of Ewing sarcoma of the skull base with exceedingly rare locations (including the area of the sphenoid bone, its wings, sinus, and adjacent structures). Ewing sarcoma is usually diagnosed in children. The peak incidence is registered in patients aged 10–15 years, whereas adults and children under 5 years of age are very unlikely to develop this disease. In this article, we also report a case of Ewing sarcoma of the skull bones affecting the sphenoid bone and sphenoid sinus. The patient has undergone surgery followed by chemoradiotherapy. High invasion potential (tumor spread in several directions), high malignancy, and compression of the adjacent structures of the brain make the analysis of Ewing sarcoma located in areas that cannot be easily approached particularly interesting for neurosurgeons, since surgery is the main treatment option for such patients.
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Kutin et al. (2021) conducted a case report in Primary Ewing sarcoma of the sphenoid bone (n=1). Surgery followed by chemoradiotherapy was evaluated. A 17-year-old patient with primary Ewing sarcoma of the sphenoid bone and sphenoid sinus was treated with surgery followed by chemoradiotherapy.
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