Key result
Abnormal lipid metabolism fuels colorectal cancer growth and metastasis by promoting an immunosuppressive tumor microenvironment.
Why the study?
Abnormal lipid metabolism is involved in colorectal cancer progression and its interaction with the tumor microenvironment is complex and not fully understood.
This review highlights the remodeling roles of lipid metabolism crosstalk between colorectal cancer cells and the tumor microenvironment.
Answers are grounded in this paper and cite their sources.
Supports lipid metabolism targeting in colorectal cancer; leaves open clinical efficacy pending prospective trials.
Lipid is a key component of plasma membrane, which plays an important role in the regulation of various cell biological behaviors, including cell proliferation, growth, differentiation and intracellular signal transduction. Studies have shown that abnormal lipid metabolism is involved in many malignant processes, including colorectal cancer (CRC). Lipid metabolism in CRC cells can be regulated not only by intracellular signals, but also by various components in the tumor microenvironment, including various cells, cytokines, DNA, RNA, and nutrients including lipids. In contrast, abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells. In this review, we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.
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Zhong et al. (2022) conducted a review in Colorectal cancer. Abnormal lipid metabolism was evaluated. Abnormal lipid metabolism provides energy and nutrition support for malignant growth and metastasis of colorectal cancer cells, and remodels the tumor microenvironment to promote immunosuppression.
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