Key result
Dysregulated lipid metabolism, cellular stress, and intestinal microbiota offer novel therapeutic targets for colorectal cancer.
Why the study?
Lipid metabolism represents a targetable metabolic vulnerability in colorectal cancer, but its complexity and interplay with microbiota and cellular stress responses require further understanding.
Population
Colorectal cancer patients and preclinical germfree and colonized mice
Design
Review
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May identify new colorectal cancer therapy targets; leaves open their clinical utility pending prospective trials.
Dysregulated lipid metabolism, cellular stress, and intestinal microbiota interplay presents potential diagnostic, prognostic, and therapeutic targets in colorectal cancer.
A 2021 study conducted a review in Colorectal cancer. Dysregulated lipid metabolism was evaluated. Dysregulated lipid metabolism, cellular stress responses, and the intestinal microbiota play crucial roles in colorectal cancer and present potential targets for novel therapeutic strategies.
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