Key result
Veno-arterial ECMO was not associated with a significantly different risk of acute kidney injury compared to veno-venous ECMO in adult patients (OR 1.54, 95% CI 0.75-3.16, p=0.235).
Why the study?
The risk of acute kidney injury among adult patients receiving different types of extracorporeal membrane oxygenation remains unclear.
Does VA ECMO compared to VV ECMO change the risk of acute kidney injury in adult patients requiring ECMO?
Meta-Analysis (n=1,112)
Does VA ECMO compared to VV ECMO change the risk of acute kidney injury in adult patients requiring ECMO?
The risk of acute kidney injury and the need for renal replacement therapy do not differ significantly between adult patients receiving VA ECMO and VV ECMO.
No significant AKI difference by ECMO mode; leaves open whether cannulation strategy influences renal outcomes in adults.
Acute kidney injury (AKI) has been reported as one of the most common complications in patients receiving extracorporeal membrane oxygenation (ECMO), yet the risk of AKI on different types of ECMO remains unclear. This meta-analysis aimed to compare risk of AKI among adult patients requiring different types of ECMO. Two authors independently performed a literature search using PubMed, Web of Science, and Embase, encompassing publications up until Arpril 20, 2020 (inclusive). The number of AKI patients, non-AKI patients, patients required RRT and patients not required RRT receiving different types of ECMO were derived and analyzed by STATA. The results indicated there was no significant difference in risk of AKI (OR, 1.54; 95% CI: 0.75-3.16; P = 0.235) and severe AKI required RRT (OR, 1.0; 95% CI: 0.66-1.5, P = 0.994) in patients receiving different types of ECMO. In Conclusion, no difference in risk of AKI and severe AKI required RRT between patients receiving VA ECMO and VV ECMO. More studies are required to support the findings.
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Mou et al. (2020) conducted a meta-analysis in Acute kidney injury in patients receiving extracorporeal membrane oxygenation (ECMO) (n=1,112). Veno-arterial (VA) ECMO vs. Veno-venous (VV) ECMO was evaluated on Risk of acute kidney injury (AKI) (OR 1.54, 95% CI 0.75-3.16, p=0.235). Veno-arterial ECMO was not associated with a significantly different risk of acute kidney injury compared to veno-venous ECMO in adult patients (OR 1.54, 95% CI 0.75-3.16, p=0.235).
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