Key result
Combining surgery and radiotherapy linked to ~46% two-year overall survival versus either modality alone.
Why the study?
The treatment outcomes and prognostic factors for clinically localised angiosarcoma of the scalp and face were not well characterized.
Does multimodal treatment including surgery and radiotherapy improve overall survival in patients with clinically localised angiosarcoma of the scalp and face?
Population
48 patients with clinically localised angiosarcoma of the scalp and face treated between 1987 and 2009
Comparison
Multimodal treatments including surgery and radiotherapy versus surgery or radiotherapy alone or neither
Design
Retrospective cohort analysis
Follow-up
Median 13.7 months (range 2.5-105.9 months)
Authors
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Multimodal surgery plus radiotherapy was associated with higher survival; hypothesis-generating and requires prospective validation before changing practice.
Cohort (n=48)
Does multimodal treatment including surgery and radiotherapy improve overall survival in patients with clinically localised angiosarcoma of the scalp and face?
Absolute Event Rate: 45.8% vs 11.1%
p-value: p=<0.0001
Multimodal treatments including surgery and radiotherapy are effective in improving overall survival for patients with angiosarcoma of the scalp and face.
Ogawa et al. (2012) conducted a cohort in clinically localised angiosarcoma of the scalp and face (n=48). Surgery and radiotherapy vs. Surgery or radiotherapy alone, or neither was evaluated on 2-year overall survival (p=<0.0001). Treatment with both surgery and radiotherapy yielded a significantly higher 2-year overall survival (45.8%) compared to either modality alone (11.1%) or neither (0%) (P<0.0001).
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