What question did this study set out to answer?

To review clinical evidence evaluating the efficacy, safety, and dosing of tetrahydrocannabinol (THC) and cannabidiol (CBD) formulations for cancer-related pain.

August 31, 2017Annals of Palliative MedicineOpen Access

A selective review of medical cannabis in cancer pain management

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Authors

ABAlexia BlakeIntegrity Testing Laboratory (Canada)BWBo WanChina General Nuclear Power Corporation (China)LMLeila MalekIslamic Azad University Central Tehran Branch

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Implication

Literature review reveals cancer pain reduction with cannabinoid therapies in advanced cancer patients, highlighting the need for larger randomized trials.

Key Points

To review clinical evidence evaluating the efficacy, safety, and dosing of tetrahydrocannabinol (THC) and cannabidiol (CBD) formulations for cancer-related pain.
Literature search of Medline between 1975 and 2017 identifying clinical trials that evaluated THC or CBD for managing cancer pain.
Identified and evaluated five clinical studies, ranging from early pilot trials to double-blind placebo-controlled trials.
Assessed formulations including oral THC capsules, THC oromucosal sprays, and THC:CBD oromucosal sprays (nabiximols) across doses of 2.7–43.2 mg/day THC and 0–40 mg/day CBD.
All five reviewed clinical studies demonstrated evidence of cancer-associated pain reduction following cannabinoid therapy.
Significant analgesia occurred at daily doses as low as 2.7–10.8 mg THC combined with 2.5–10.0 mg CBD, though evidence for superior pain relief at higher doses remained conflicting.
Reported adverse events included drowsiness, hypotension, mental clouding, nausea, and vomiting, with overall statistical power constrained by small sample sizes.

Cite This Study

Blake et al. (2017) studied this question.

synapsesocial.com/papers/6aae0af2322a2d038800ee0d https://doi.org/10.21037/apm.2017.08.05

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Implication

Literature review reveals cancer pain reduction with cannabinoid therapies in advanced cancer patients, highlighting the need for larger randomized trials.

A selective review of medical cannabis in cancer pain management

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Implication

Key Points

Cite This Study

A selective review of medical cannabis in cancer pain management

Discussion

Member takes

Implication

Key Points

Cite This Study

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