Answers are grounded in this paper and cite their sources.
An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position. [reaction: see text]
No takes yet. Share an insight, caveat, or question.
Amat et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: