Key result
Elevated serum FGF21 correlates with increased carotid IMT in women but not men.
Why the study?
Whether serum FGF21 is independently associated with atherosclerotic diseases remains unclear.
Are serum FGF21 levels independently associated with carotid intima-media thickness in Southern Chinese subjects?
Population
670 Southern Chinese subjects who underwent carotid IMT measurement
Comparison
Serum FGF21 levels association with carotid IMT
Design
Cohort study
Authors
Loading...
Suggests sex-specific FGF21 role in subclinical atherosclerosis; hypothesis-generating and needs longitudinal validation before clinical consideration.
Cohort (n=670)
Are serum FGF21 levels independently associated with carotid intima-media thickness in Southern Chinese subjects?
Effect estimate: r=0.32 in women
p-value: p=<0.001
Elevated serum FGF21 levels are independently associated with carotid atherosclerosis in women, independent of established cardiovascular risk factors.
Chow et al. (2013) conducted a cohort in Carotid atherosclerosis (n=670). Elevated serum FGF21 levels vs. Lower serum FGF21 levels was evaluated on Carotid intima-media thickness (IMT) (r=0.32 in women, p=<0.001). Elevated serum FGF21 levels were independently associated with increased carotid intima-media thickness in women (r=0.32; P<0.001), but not in men (r=0.06; P=0.305).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: