Key result
Dietary resveratrol prevents abdominal white fat accumulation and lowers carbohydrate oxidation ~9% in obese rats.
Why the study?
Resveratrol has several beneficial health properties, but its effect on obesity pathogenesis and nutrient metabolic profile in non-high fat-fed obese OLETF rats was unclear.
Does dietary resveratrol prevent obesity and alter the metabolic profile of nutrients in obese OLETF rats?
Does dietary resveratrol prevent obesity and alter the metabolic profile of nutrients in obese OLETF rats?
Absolute Event Rate: 4.43% vs 4.87%
p-value: p=<0.05
Dietary resveratrol may prevent obesity by altering nutrient metabolic profiles and enhancing fat metabolism in an obese rat model.
Hypothesis-generating in obese rat model; leaves open human translation pending clinical trials.
BACKGROUND: Resveratrol (trans-3,4',5-trihydroxystilbene) is a naturally occurring phytoalexin produced by plants in response to various stresses. Several studies have shown that resveratrol is present in significant amounts in a variety of human diets, including wines, grapes, berries, and peanuts, and it possesses several beneficial health properties, such as atheroprotective, anti-obesity, anti-cancer, anti-inflammatory and antioxidant activities. In this study, we evaluated the effect of resveratrol on the pathogenesis of obesity and the metabolic profile of nutrients in non-high fat-fed obese OLETF rats. RESULTS: Although lipid parameters in the serum and liver were not changed, the accumulation of abdominal white adipose tissues was markedly prevented in resveratrol diet-fed OLETF rats after 4 weeks of feeding. The results of the respiratory gas analysis indicated that dietary resveratrol induced the partial enhancement of fat metabolism and sparing actions for carbohydrate and protein at 1 week and 3 weeks of feeding in OLETF rats. Additionally, the adipose mRNA level of carnitine palmitoyltransferase in the resveratrol diet-fed OLETF rats was higher than the control rats after 4 weeks of feeding. CONCLUSION: Our study demonstrated that dietary resveratrol can prevent obesity through a change in the metabolic profile of nutrients in obese OLETF rats.
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Nagao et al. (2013) studied Obesity (n=12). Dietary resveratrol vs. Control diet was evaluated on Carbohydrate oxidation at 1 week (g/day/100 g body weight) (p=<0.05). Dietary resveratrol prevented abdominal white adipose tissue accumulation and significantly lowered carbohydrate oxidation (4.43 vs 4.87 g/day/100 g body weight, p<0.05) in obese OLETF rats.
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