Key result
Brachial artery postischemic hyperemia duration shows no correlation with ipsilateral nailfold capillary diameter changes.
Why the study?
It is unclear whether endothelial function in conduit arteries correlates with endothelial function in the supplied microvascular beds.
Does postischemic vasodilation of the brachial artery correlate with postischemic hyperemia in the adjacent microvascular bed?
Observational (n=153)
Does postischemic vasodilation of the brachial artery correlate with postischemic hyperemia in the adjacent microvascular bed?
Effect estimate: r = 0.076
p-value: p=0.3493
Endothelial function responses in conduit arteries do not correlate with those in the adjacent microvascular bed, suggesting different regulatory mechanisms.
Endothelial responses in microvessels versus conduit arteries remain uncertain; leaves open need for standardized, comparable testing methods.
BACKGROUND: Endothelial cells secrete different mediators depending on biochemical and/or biophysical conditions, which can lead to vasodilation or vasoconstriction, respectively. Impaired endothelial responsiveness to specific vasodilator stimuli has been used as a surrogate marker of cardiovascular risk. Multiple methods allow testing endothelial responses in both microvessels and conduit arteries, but it is still unclear whether there is a relationship in endothelial function between these two different vascular beds. MATERIAL AND METHODS: In order to examine, whether such macrocirculatory data might correlate with data obtained in the supplied microvessels, a parallel investigation in the brachial artery (BA) and the supplied nailfold capillaries was performed. The duration and amplitude of the postischemic hyperemia (stasis in the vasculature of the left arm using a blood pressure cuff for 3 minutes) were measured (ultrasound technique) and simultaneously the amplitude and duration of the postischemic hyperemia in ipsilateral nailfold capillaries (intravital capillaroscopy). RESULTS: There was absolutely no correlation between the duration (n = 153, r = 0.076, p = 0.3493) of the diameter increase in the BA and in ipsilateral nailfold capillaries. CONCLUSION: The regulation of the cutaneous microcirculation did not follow diameter changes of the conduit artery (BA) but seems to be dominated by the precapillary arterioles.
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Jung et al. (2011) reported an observational. Postischemic hyperemia (stasis using blood pressure cuff) was evaluated on Correlation between the duration of the diameter increase in the brachial artery and in ipsilateral nailfold capillaries (r = 0.076, p=0.3493). Postischemic hyperemia duration in the brachial artery showed no correlation with diameter changes in ipsilateral nailfold capillaries (r = 0.076, p = 0.3493).
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